Thursday September 25, 2008


Q: Does Phenytoin (Dilantin) get cleared by hemodialysis or hemoperfusion?

A; No (clinically insignificant removal)


Clinical significance:

1. In Phenytoin toxicity/overdose, Hemodialysis or hemoperfusion are ineffective for enhancing elimination.

2. Hemodialysis patients do not require extra dosing post dialysis though require frequent monitoring due to lower albumin level.