Tuesday September 9, 2008
Procalcitonin, C-reactive protein and now Chromagranin A in Sepsis. JUST ADD IT ON

Dan Zhang from France studied the link between Chromagranin A (CGA) and systemic inflammatory response syndrome (SIRS). CGA is a stress marker released along with catecholamine by adrenal medulla.

They measured CGA, procalcitonin, and C-reactive protein level in 53 patients and 14 controls. They also assessed Simplified acute physiological score (SAPS).

Results: Serum CGA level was significantly elevated in patients where infection is associated with SIRS with a median value of 138.5mcg/L as compared to controls (p<0.001).
CGA concentration also positively with procalcitonin and C-reactive protein.

Conclusion: Patients with CGA concentration higher then 71 mcg/L have a significantly shorter survival and was independent of SAPS score.


Reference: Click to get abstract/article

Zhang D, Lavaux T, Lavigne T, Castelain V, et al. Serum concentration of chromogranin A at admission: An early biomarker of severity in critically ill patients. Annals of Medicine, 21 August 2008